Post-ischemic myocardial fibrosis occurs independent of hemodynamic changes
نویسندگان
چکیده
منابع مشابه
Post-ischemic myocardial fibrosis occurs independent of hemodynamic changes.
OBJECTIVES Myocardial fibrosis is a major component of ventricular remodeling after large myocardial infarction (MI). The present study tests the hypothesis that post-ischemic myocardial fibrosis can occur independent of hemodynamic changes. METHODS A mouse model of distal left coronary artery ligation was established to induce a small infarct (less than 15% of the left ventricle) in order to...
متن کاملClinical and hemodynamic studies of myocardial fibrosis.
In many instances mv ocardial fibrosis mimics constrictive pericarditis so closely, both hemo-dynamically and clinically that the diagnosis can be made with certainty only at operation or autopsy. In the 3 cases presented here certain distinctions can be made that suggest that the differentiation can sometimes be made by careful analysis of pressure contours from the right heart. E XTENSIVE rep...
متن کاملHemodynamic aspects of diffuse myocardial fibrosis.
MYOCARDIAL fibrosis is defined as a diffuse replacement or invasion of the myocardium by fibrous connective tissue to such an extent that there is interference with the action of the heart. Eleven patients with this disorder have been studied. The purpose of this paper is to report the hemodynamic findings in these patients as studied by various standard methods including right heart catheteriz...
متن کاملThe Hemodynamic Effects of Drugs on Myocardial Oxygen Use
The circulatory responses to high equinalgesic doses of morphine are compared with those of pethidin. The decrease in mean arterial blood pressure in case of morphine was 28p.c., with a paralleled and identical decrease in total peripheral resistance and no negative inotropic effects. Pethidine decreased blood pressure 54p.c., as a result of peripheral vasodilation of 46p.c. and a sharp drop...
متن کاملPressure-independent effects of angiotensin II on hypertensive myocardial fibrosis.
Angiotensin II (Ang II) is implicated in the proinflammatory process in various disease situations. Thus, we sought to determine the role of Ang II in early inflammation-induced fibrosis of pressure-overloaded (PO) hearts. PO was induced by suprarenal aortic constriction (AC) at day 0 in male Wistar rats, and they were orally administered 0.1 mg/kg per day candesartan every day from day -7. Thi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2003
ISSN: 0008-6363
DOI: 10.1016/s0008-6363(03)00519-4